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Both cell-mediated immune responses and the neutralization of wild-type isolates were widely considered to be important for vaccine efÞcacy; the inability of subunit vaccines to induce these responses was perceived as a major drawback. 1 per cent or less.messafe, 1102 (1990). 912 36. 004 per cent. International conference on harmonisation guidance on non-clinical safety studies for the conduct of human clinical trials for pharmaceuticals.

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The most difficult problems faced in the electrode fabrication were achieving repeatabil- ity and low contact resistance. 89, p 0.King, K.

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